First Genetic Test for Predicting IVF Success

A researcher at Albert Einstein College of Medicine of Yeshiva University has helped to develop the first genetic blood test for predicting the chances that in vitro fertilization (IVF) will lead to a successful pregnancy. The test, reported in the online medical journal PLoS ONE, is based on the finding that different subtypes of the FMR1 gene (also known as the fragile X mental retardation gene) in potential mothers are associated with significantly different chances of conceiving with IVF.
"This is the first evidence that a specific gene appears to be directly associated with IVF outcomes," said David Barad, M.D., associate clinical professor of epidemiology & population health and of obstetrics & gynecology and women's health at Einstein and one of the study's senior authors. Dr. Barad is also director of assisted reproduction at the Center for Human Reproduction (CHR) in New York City.
"Our research also suggests the FMR1 gene, some forms of which are known to predict premature ovarian failure, could be used to predict at what age a woman's fertility is going to start decreasing," he added.
The study also supports the belief that autoimmunity (immunity to one's own cells or tissues) plays a role in infertility -- a controversial topic among reproductive medicine specialists.
The study involved 339 female infertility patients who underwent a total of 455 IVF cycles at CHR. The researchers investigated the relationship between three different FMR1 genotypes and pregnancy outcomes and autoimmunity levels. Women with the "normal" FMR1 genotype had a 38.6 percent pregnancy rate; those with the "heterozygous-normal/high" genotype had a 31.7 percent pregnancy rate; and women found to have the "heterozygous-normal/low" genotype had a 22.2 percent pregnancy rate.
The genotype associated with the lowest pregnancy rate (heterozygous-normal/low) was also associated with increased measures of autoimmunity. Women with this genotype also had a higher incidence of polycystic ovary syndrome (a common cause of infertility), which is thought to have an autoimmune component. "Previous studies have suggested that autoimmunity plays a role in infertility," said Dr. Barad. "Now, for the first time, we have a potential genetic mechanism that underlies several different threats to infertility."
The cost of the blood test for the FMR1 should be relatively low -- comparable to screening tests for Tay-Sachs and other genetic diseases. While the FMR1 gene test is not yet clinically available, "It's likely that the findings will lead to clinical applications in the future," said Dr. Barad.
"Any test that is proven to have predictive value for a woman's fertility would give her a heads up in terms of planning a family," he added. "For instance, if a woman planning to go to law school or medical school learns she has a certain amount of risk of losing her ovarian function before she is 35, she may choose to bank her eggs or try having children at an earlier age, rather than delay."

Vitrolife receives patent protection for Swemed Sense needle in European markets

Swemed Sense™ is a unique needle that is used for the collection of oocytes in connection with IVF. The approved patent means that Vitrolife has both design protection and product patent protection for Swemed Sense™ in strategically important European markets. A patent has also been applied for in other prioritized markets.

A recently presented study shows that Swemed Sense™ gives less pain and bleeding during the collection of oocytes, compared with a conventional needle.

Swemed Sense™ has a unique design, as advantages from both thin and thick needles are combined in one and the same needle. Swemed Sense™ is designed with a thinner front part and tip so as to minimize tissue damage, bleeding and pain. The rear part of the needle has a larger diameter, which means that the needle is stable and at the same time maintains flow and speed.

The market for needles used in the collection of oocytes for IVF is estimated to amount to approximately 40 million Euros globally.

Couple's baby joy after spending £54k on IVF treatment

When she lost her son Jack to meningitis, just weeks before his second birthday, ­Jennifer Heneghan’s world fell apart.
She was a single mum and ­everything she did revolved around her little boy. But as she battled to cope with her grief at just 23, ­doctors dealt her another ­devastating blow – she would never be a mum again.
But despite being told she was infertile, Jennifer refused to give up on her dream of having another child.
And now, after years of trying and £54,000 spent on IVF treatment she has finally given birth to her longed-for baby.
Jennifer, 33, says: “I didn’t want to replace Jack. Nothing ever could. I simply wanted to be a mum again. To lose a child is unbearable; to then be told you can never have any more shatters you.
“I just couldn’t give up and thank goodness we didn’t. Now when people ask I say I have two sons.”
Jack was born when she was 21. Though she split with his dad shortly after the birth and life hadn’t turned out as she’d planned it, as a single mum at 21, Jennifer couldn’t have been happier.
“Jack was my world. I loved being a mummy and the two of us were joined at the hip,” she recalls.
But just a few weeks before his second ­birthday, Jack went off his food and became clingy and lethargic.
A worried Jennifer took him to the GP who prescribed ­antibiotics for a ­suspected infection.
But as the days passed Jack got worse and one night, with his temperature soaring, he seemed difficult to rouse.
Jennifer rushed him to ­Wexham Park Hospital in Slough, Berkshire, but was advised to take him home and continue with the medication.
Only hours later Jack’s eyes became glazed and he started gasping for breath.
Jennifer’s mum called an ambulance and he was rushed back to the hospital. “A crash team were waiting and whisked him straight off,” ­Jennifer remembers. “We were taken to the relatives’ room and that’s when I heard the ‘M’ word.”
She was told Jack had ­suffered a heart attack caused by ­meningitis. He was on life support.
“When the doctor told me to call Jack’s family, in my heart I knew he was never coming home. A piece of me died right then,” she says.
Just three hours later Jack’s fight was over. “I screamed in shock and broke down,” recalls Jennifer. “I don’t even remember the next few weeks. I should have been planning his second birthday, not his funeral.”
In time Jennifer moved on and fell in love with best friend Marie’s brother Kevin, a National Grid engineer.
“It helped that Kevin had known Jack,” says Jennifer. “I don’t think I could have been with someone who didn’t know him because he was such a big part of my life.”
The couple discussed kids and both agreed they wanted to try. “I didn’t want to replace Jack but I knew life would always be empty without ­children for me,” she says. “I ­wanted to be a mum and I knew Kevin would be an excellent dad.” The couple decided to get married the following ­summer but started trying for a baby straight away.
But the wedding came and went with no news so they decided to ask doctors for some advice.
And after being referred to hospital for tests, ­Jennifer’s dreams were about to be destroyed.
“The consultant ­explained that I had ­developed a condition that had fused my tubes ­together,” ­explains Jennifer. “I asked what they could do and he just shook his head and said nothing. I was ­infertile.” Jennifer was only 25.
“It took a few minutes for it to sink in. I was stunned. I’d got ­pregnant so easily with Jack it seemed impossible.Apparently now I had more chance of winning the lottery than having a baby.”
For Jennifer the pain of losing Jack came flooding back. He’d been her only chance at motherhood and she’d lost him. The couple asked to have her tubes flushed to remove the blockages but it failed.
“It looked like there really was no hope. But then Kevin suggested we cancel a holiday we were ­planning and put the money ­towards IVF instead,” she says.
But four painful attempts and £25,000 later, Jen, who manages a care home for adults with learning difficulties, was still not pregnant.
“It was like being on a rollercoaster,” she ­recalls. “One minute up, the next minute ­heartbroken at another failed attempt.”
And then to top it all off Jennifer developed Bell’s Palsy – a weakness of the facial muscles – which made her look like she’d had a stroke.
“The doctor said it could be stress-induced because of the worry of the IVF,” she says. “He advised me to start looking after myself and he was right. After four cycles in as many years everything had taken a back seat to IVF and we needed a break.”
For the next three years Jennifer and Kevin, now 35, ­focused on their ­relationship – enjoying holidays and time ­together without the pressure of treatment cycles. But the yearning for a baby got stronger.
So in 2008 the couplecontacted London’s ­Assisted Reproduction and Gynaecology ­Centre and signed up for another course.
Just three weeks later, Jennifer found out she was ­pregnant with twins.
But their joy was short-lived after ­Jennifer miscarried at six weeks.
“I told Kevin I wasn’t sure I could go through it all again,” she says. By this time Jennifer was 33 and the couple had already forked out a huge £40,000.
Over the eight years they had been trying to conceive, the couple spent all their money on IVF giving up holidays and even missing out on home improvements. They had taken out one loan of £4,000 early in the process.
But they agreed to have one last shot using the two frozen eggs they had left. And when they realised it would cost another £14,000 to have the eggs thawed and implanted they turned to Jen’s parents for the money.
It was their first frozen cycle and they were apprehensive, ­especially when one egg didn’t survive. But the other did and two weeks later, Jennifer was pregnant again.
For Jennifer, the whole ­pregnancy was fraught with worry. She was terrified the worst would happen again, especially when a blood clot developed in her womb.
But week after week, her regular scans showed their baby clinging on. At 14 weeks they found out it was a boy. Then at 34 weeks ­Jennifer went into early labour and had baby Tiernan. At just 5lb 10oz he was taken to baby care, but the next day she got to hold him. At 18 days he was allowed home.
And now he’s seven months old. “After what we went through it doesn’t matter what he cost because we feel like we have won the ­lottery,” Jennifer beams. “We never gave up on our dream and finally it came true. I can never thank Mum and Dad enough because the money they gave us bought us Tiernan.”
Jennifer thinks Tiernan is the image of his big brother Jack.
“People always used to tell me how Jack was cheeky but adorable at the same time – and Tiernan is the same,” she says. “The older he gets the more he looks like Jack with the same mousey hair and blue eyes.”
And while Jennifer ­admits being a mum in her 30s is much more tiring, she’s ­loving every minute.
“I don’t take anything for granted and I’m afraid to say he has me wrapped around his little finger.
“He’s the miracle I’ve waited years for and he’s here in my arms at last. When I’m cuddling him I look at his little face and know it was worth every minute of the pain and ­anguish of IVF.”
Needless to say the family had their best Christmas ever last month.
“There’s only one word to describe the presents piled under our tree – shameless!” she laughs.
“I never thought I’d be ­opening presents with a child again on Christmas Day. How could I not go over the top with him?
“It used to be a sombre day because it’s all about children and just reminded us what we couldn’t have. Now Tiernan is the best gift of all.”

Clowning helps IVF patients become pregnant: study

Dr. Shevach Friedler an infertility doctor with the Infertility and IVF unit at Assaf Harofeh Medical Center, in Zrifin, Israel, led a study of the effects of a bedside encounter with a professional medical clown on the pregnancy rate of women undergoing in-vitro fertilization (IVF).
Dr. Friedler and colleagues tracked 219 women undergoing IVF treatment at the medical center and, over a period of a year, treated half of them to a medical clown's 15-minute routine of jokes, magic tricks and other clowning immediately after their embryos were implanted. The clown’s routine was created especially for the study by Friedler and a colleague.
The results showed 36.4 percent of women exposed to clowning immediately after embryo transfer became pregnant, while only 20.2 percent of the controls became pregnant. Dr. Friedler said the reason was probably because the clowning reduced the stress of what for many was many years of grueling IVF treatments, but this is not certain. It is also unclear what role, if any, stress may play in the success of IVF treatments.
Dr. Friedler, who is also trained in movement and mime, originally thought of the research after reading about laughter as an anti-stress mechanism. He realized that IVF patients are often extremely stressed, and wondered if relieving that stress through clowning at a crucial moment in the treatment could help.
Dr. Friedler and colleagues conclude that medical clowning may be a beneficial adjunct to IVF treatments and it deserves further investigation. Medical clowning is already used to good effect in hospitals in Europe, Australia, North America and Israel, particularly in children’s hospitals.
Dr. Friedler also pointed out that clowning is “one of the least hazardous interventions in our field.” Other methods of reducing stress could also be investigated. The findings are reported in the journal Fertility and Sterility.
More information: The effect of medical clowning on pregnancy rates after in vitro fertilization and embryo transfer (IVF-ET), Shevach Friedler, M.D et al., Fertility and Sterility, published online 06 January 2011, doi:10.1016/j.fertnstert.2010.12.016

This is no light bill

Antilla is not just a landmark, a month after Mukesh Ambani moved in, it also generated the city’s biggest power bill for a residence: Rs 70 lakh(152,000 USD approx)

The asymmetrical stack of floors is lit-up like a jewellery box, illuminating the indigo sky, its opulence casting everything around it into a paler shade of their selves. Mukesh Ambani’s Godzilla-sized home, Antilla, has just notched up another headline. In the one month since he moved in with wife Nita and their three children, the tycoon has generated a power bill of Rs 70,69,488, the city’s highest residential electricity bill.

According to the bill for the month of September, made available to TOI, Antilla consumed 6,37,240 units of power. To put it in perspective an average Mumbai household equipped with all electronic amenities consumes 300 units per month. Ambani was in fact, as per BEST norm, given a discount of Rs 48,354 for prompt payment. The 70 lakh quoted earlier is minus this amount. Experts say the RIL boss’s tariff is roughly equivalent to the monthly power bill of 7,000 homes in Mumbai. The 27-storey Antilla, named after a mythical island, with its three helipads, 50-seater theatre, nine elevators, swimming pool and residential quarters takes up 37,000 square meters of space which is larger than the Palace of Versailles and according to the Guardian newspaper of the UK, its estimated value is pegged at Rs 4,567 crore.

“Extensive air-conditioning and elevated parking are big energy consumers,” says a BEST official not wishing to be quoted. Further, he adds, the building is lit up through the night, showcasing the bling. Though, a report in the Forbes magazine says that a four-storey hanging garden was especially built as an energy-saving device, to keep the interiors cool in summers.

Perhaps it is taking effect, for in October their power bill marginally came down to Rs 61,28461, for consumption of 5,96,800 power units. The family is among BEST’s high-tension consumer, a category created for bulk users. Save for a small part of the building which is designated as office space where commercial rates are applicable, the lower residential rates apply to the rest of the building. But even here it’s fortunate that Antilla is located where it is. Altamount Road falls under the BEST radar which has the lowest tariff among all power suppliers. Had brother Anil’s Reliance Energy been their power suppliers, Mukesh’s bill, as half of Mumbai can vouch, would have been further inflated.

Antilla, the world most expensive house to get fine china worth $1million

When you live in the world’s most expensive house, Antilla, you wouldn’t want to settle for anything but the best to fill it up. Hence when the lady of the house, Neeta Ambani, decided to go for crockery shopping, she planned to stock up her cabinets with 25,000 pieces of 106-year-old Japanese brand Noritake. It is estimated that the cost of this collection will total up to $1million. However the wife of Mukesh Ambani, world’s fourth richest man, decided to save up a bit here. She is rumored to head to Sri Lanka to collect her chinaware as Noritake stuff is 70-80% cheaper there than the rest of the world. Times of India reports, ‘A 50-piece dinner set with 22 carat gold/platinum trimmings could cost $300-500 in Sri Lanka while the same would be priced between $800 and $2,000 in India. Multiply that by 500 (to cover Nita Ambani's 25,000-piece order) and the price could have hit $1 million at the upper end in India.’ What do you think of her bargain-hunting move as lady of the ‘world’s most expensive’ house?:))

Elton John: Goodbye Yellow Brick Road, hello nappies and sleepless nights

Zachary Jackson Levon Furnish-John was born weighing 7lb 15oz, to an unnamed woman in California.
There was speculation that his second name was a tribute to Sir Elton’s friendship with the late singer Michael Jackson and Levon is the title of a song from Sir Elton’s 1971 album Madman Across The Water.
The couple are believed to have paid an agency more than £100,000.
“We are overwhelmed with happiness and joy at this very special moment,” Sir Elton, 63, and Mr Furnish, 48, said in a joint statement. “Zachary is healthy and doing really well, and we are very proud and happy parents.”
It was not clear whether the birth was natural, induced or the result of an elective Caesarean. Mr Furnish, as the younger man by 15 years, is thought more likely to be the sperm donor.
He said it typically took 18 months for a couple to complete the process, and the total cost for a same-sex couple, including medical and legal expenses, was about $150,000, including a $20,000 to $30,000 fee for the surrogate mother.
Prospective parents usually meet the surrogate several times before the pregnancy, and provide the agency with photographs of the baby up to the age of 24 months.
Age was considered when prospective parents applied: “One might be a bit older but the other might be younger. We do worry about longevity but it averages out.”
Sir Elton and Mr Furnish’s civil partnership was formalised in 2005 and the singer had spoken of his desire to become a father, announcing last autumn that he had overcome his doubts about his age and wanted to adopt a 14-month-old orphan boy from Ukraine.
The plans were thwarted by Ukrainian laws which do not recognise same-sex civil partnerships. British law changed in April when it became legal for two men to have a child by a surrogate and for both men’s names to appear on the birth certificate as legal parents.
Surrogacy is still tightly regulated in Britain and couples often consider travelling abroad, where the rules are less strict.
Sir Elton’s announcement was greeted with concern from some groups. Josephine Quintavalle, founder of Comment on Reproductive Ethics, said: “Although I am sure Elton’s child will not want for anything, money is not everything. There is very much an age for being a parent and an age for being a grandparent.
“It would be very difficult to adopt a child at 63 but we seem to have a different approach to approving surrogacy parents.”
Andrea Williams, head of Christian Concern, said: “Children are not commodities. Just because you can buy or access something does not give you the right to do so.”
Elizabeth Hurley, the model and actress, was among the first to offer her best wishes, writing on the Twitter microblogging service: “Massive congratulations to David and Elton on having their beautiful son. Can’t wait for my first cuddle.”
Piers Morgan, who spoke to Sir Elton on ITV’s Life Stories, was caught out by the news, writing: “Feel such a fool – Sir Elton never even hinted he was pregnant during our interview.”
The singer Boy George commented: “What does it matter, gay or straight, if they make great loving parents?”