The Ramblings of a Middle Aged Fertility Physician whose life revolves around Eggs, Sperms & Embryos....
Wednesday, January 26, 2011
Sperm donor campaign worth a shot!
A racy ad campaign to fight a sperm donor shortage has had spectacular results for an Adelaide IVF clinic.
Fertility specialist Repromed's "Don't Waste Your Sperm" advertisements, which recently appeared in men's magazine FHM, have led to a thousandfold increase in local inquiries.
The full page advertisement directed readers to an online test which received more than 100,000 hits.
Almost 5000 people completed the survey, with more than 1000 men going on to approach the clinic for more information.
The cheeky campaign urged men to take an online test to assess their donor potential and then allowed them to boast about their results by posting them on Facebook or Twitter.
"Take this simple test to see if your sperm has the potential to father more kiddies than Brangelina," it read.
While numbers of interested men have soared, the exhaustive screening process meant the campaign may have yielded just three possible donors.
"But due to what it entails, and that every donor can provide sperm to 10 families, it is still a really positive result," said medical director Dr Richard Henshaw.
Tuesday, January 25, 2011
Hyderabadi Rocks!!!
Monday, January 24, 2011
India Marches Against Corruption - There is still some hope!
Thousands of people will take to streets to demand effective anti-corruption law
J M Lyngdoh, Swami Agnivesh, Kiran Bedi, Anna Hazare, Prashant Bhushan, Most Reverend Vincent M Concessao Archbishop of Delhi and others will march from Ramlila Grounds to Jantar Mantar on 30th January, the day Mahatma Gandhi was assassinated, at 1 pm to demand enactment of a law to set up an effective anti-corruption body called Lokpal at the Centre and Lokayukta in each state (the existing Lokayukta Acts are weak and ineffective).
Kiran Bedi, Justice Santosh Hegde, Prashant Bhushan, J M Lyngdoh and others have drafted this Bill. Please visit the web-site for full text of this Bill. A nation wide movement called “India Against Corruption” has been started by Sri Sri Ravi Shankar, Swami Ramdev, Swami Agnivesh, Most Reverend Vincent M Concessao Archbishop of Delhi, Kiran Bedi, Arvind Kejriwal, Anna Hazare, Devinder Sharma, Sunita Godara, Mallika Sarabhai and many others to persuade government to enact this Bill.
Mrs Sonia Gandhi recently announced that Lokpal would be set up. However, the Lokpal suggested by the government is only a showpiece. It will have jurisdiction over politicians but not bureaucrats, as if politicians and bureaucrats indulge in corruption separately. And the most interesting part is that like other anti-corruption bodies in our country, the government is making Lokpal also an advisory body. So, Lokpal will recommend to the government to prosecute its ministers. Will any prime minister have the political courage to do that?
Please participate in large numbers in this march to persuade the government to enact the Bill drafted by the people. Please turn overleaf to read how this Bill will help in effectively checking corruption.
Can India turn around?
There was much worse corruption in Hong Kong in 1970s than we have in India today. Collusion between police and mafia increased and crime rate went up. Lakhs of people came on the streets. As a result, the government had to set up an Independent Commission Against Corruption (ICAC), which was given complete powers. In the first instance, ICAC sacked 119 out of 180 police officers. This sent a strong message to the bureaucracy that corruption would not be tolerated. Today, Hong Kong has one of the most honest governance machinery. India can also turn around if we also had similar anti-corruption body. Hong Kong government enacted ICAC Bill because lakhs of people came on streets.
Join the march on 30th January (Assembly at 1 pm at Ramlila Ground, New Delhi)
If you plan to join or volunteer with us, do call us +919717460029
How will the Lokpal Bill drafted by citizens help curb corruption?
Sunday, January 23, 2011
Crocodile swallows Nokia Phone!
Say what you will about Nokia and its inability to catch up with the Apple and Google, the company knows how to pump out a phone that can take a pounding and still work. Don’t believe me? Well, a Nokia phone was eaten by a Ukrainian crocodile and it still rang inside its stomach.
The 14-year-old crocodile Gena snatched the Nokia phone from a tourist’s hands as it was trying to take a dramatic picture of the creature. The would-be Ansel Adams of the crocodile world dropped the Nokia phone in the water and Gena quickly swallowed the delicious cellular device.
Workers didn’t believe the person but then they called the Nokia phone and it rang inside the crocodile’s tummy. While it’s a funny little tale, it appears that Nokia doesn’t make the best entrees, as Gena isn’t eating food, not playing with other crocodiles and is generally listless.
According to the Associated Press:
Dnipropetrovsk chief veterinarian Oleksandr Shushlenko said the crocodile will be taken for an X-ray next week if he continues to refuse food. Surgically removing the phone would be a last resort, he said, since incisions and stitches usually take at least three weeks to heal in reptiles and the procedure is dangerous for the animal and the vets.
“Everything will depend on where the foreign body is located,” Shushlenko said. “We don’t have much experience working with such large animals.”
God, we’re quickly changing to IntoAnimals, as this is the second animal story I’ve written in the last few days. Yesterday, we learned that Verizon 3G will help live stream the birth of a bear.
Let’s hope Gena gets better.
Saturday, January 22, 2011
Surrogacy: the brave new world of making babies
As actress Nicole Kidman becomes the latest star to take delivery from a surrogate mother, the social and moral boundaries of reproduction are becoming increasingly blurred. Hollywood stars are good at paying tribute to the production teams who helped them create their latest masterpiece. But last week, when actress Nicole Kidman and her musician husband announced the birth of a baby girl – and thanked the “gestational carrier” in whose womb she grew – they conjured up a Brave New World indeed.
In Aldous Huxley’s chilling dystopia, natural reproduction has been abolished, with children created in bottling factories and decanted, to be brought up in hatcheries and conditioning centres.
Issuing a statement on Monday, hours after shimmering tautly at the Golden Globes, Kidman said no words could adequately convey the gratitude that she and husband Keith Urban felt to those who supported them through the process, and in particular to their gestational carrier.
Yet it was precisely this inelegant euphemism for surrogate mother – perhaps an attempt by baby Faith Margaret’s biological parents to assert their authority – which calls to mind Huxley’s vision of 2540.
The pronouncement came days before singer Sir Elton John, 63, and partner David Furnish, 48, shared the first images of their baby son, born via a surrogacy arrangement on Christmas Day. The celebrity pair said they had “no clue” which of them was the father of Zachary Jackson Levon, both having contributed sperm samples to be mixed with eggs donated anonymously.
Is this just the stuff of Hollywood – or a glitzed-up mirror to a new world of reproduction, where traditional social and moral conventions are quickly changing?
Natalie Gamble is one of this country’s leading fertility lawyers, specialising in surrogacy. A lesbian mother of two children (both born via donor insemination), she won a landmark legal case last year, in which two British parents were allowed to keep a child who had been born via commerical surrogacy.
Since Britain’s first official surrogate birth, in 1985, laws have limited payments to cover only what is described as “reasonable expenses”, such as loss of income. Women cannot make a profit by “renting out” their wombs, nor can infertile couples pay such rates to surrogates, even if they live in countries with different laws.
But, last month, Mr Justice Hedley explained how he had allowed a British couple to keep their child, despite the fact that they made higher payments to a surrogate living in Illinois, in the United States, where there is no ceiling on amounts.
In making the ruling, he went further, saying that the welfare of the child was the paramount consideration,
and future cases would be rejected only in the “clearest case of the abuse of public policy”.
Ms Gamble, a partner at Gamble and Ghevaert, says: “The ruling was pretty important. It doesn’t change British law, but it shifts the focus within it, so that people know that, if they do go abroad and pay more than expenses, the chances are that those deals will be ratified afterwards.”
Support groups for surrogacy believe many women who want children but are unable to carry them will feel they have no alternative.
In October, Surrogacy UK, which brings together potential surrogates with intended parents, was forced to close its waiting lists for those seeking surrogacy, such is demand.
Kim Cotton, Britain’s first surrogate mother, was paid £6,500 when she had a child for an infertile Swedish couple, using her own eggs and the sperm of the father, 26 years ago.
Estimates suggest that, since then, about 750 children have been born in this country of such arrangements, with “expenses” payments averaging about £15,000.
Soon after the birth, Mrs Cotton, who had already had two children with her husband, said: “You can cut off all maternal feeling if you try hard enough.”
She has never met her child, nor the couple who brought her up. Now a grandmother, aged 54, she does not regret her place in British fertility history, but she believes it was both wrong and damaging that a relationship was never forged between the parties involved. A later happier agreement saw her carry twins – unpaid – for a friend with fertility problems.
Yesterday, details emerged of a surrogate mother allowed to keep her baby girl after refusing to hand her over to the prospective parents.
Explaining his ruling, Mr Justice Baker said on Friday that the woman – the biological mother of six-month-old child T – was better able to meet the girl’s needs than were the married couple, who were alleged to have a violent relationship. Surrogacy support groups insist that such disputes remain rare.
Jayne Frankland, 45, from Herefordshire, tells perhaps Britain’s most unusual surrogacy story. She is bringing up a child born via surrogacy, has acted as a surrogate three times – and in between has had four children who were conceived naturally.
She and her husband Mark had been married for more than 10 years and had undergone repeated fertility treatments in their attempts to start a family when they decided to contact a surrogate agency. After four months of insemination with Mark’s sperm, the surrogate, Susan, a mother-of-two, became pregnant with baby Abigail, who is now 14.
Three years later, to her amazement, Mrs Frankland discovered she was pregnant. Her fertility had spontaneously recovered and she was now producing eggs. Four children – Sam, 11, Charlie, 10, Elisabeth, seven, and Scarlet, three – followed.
Because of their experiences, the couple had become members of support group Surrogacy UK. Soon after Elisabeth was born, they got to know a couple who were desperate to have a child. It was their eldest child Abigail, then seven, who asked Mrs Frankland if she could have a child for somebody else “now that your tummy is mended”.
Mrs Frankland has now done that twice, giving birth to Isaac, now six, and Hector, five, for two more couples. She is currently three months pregnant for another couple. In the 14 years since Abigail was born, she belives that the stigma attached to surrogacy has almost evaporated.
“When we had Abigail, I was afraid of what people would think. I wondered how they would treat us – would they accept her? Would we be outcasts or be seen as buying a baby? Compared with how it used to be, people really don’t bat an eyelid any more.”
She acts as surrogate, she says, because of her empathy for those struggling to have a family. She believes that no one would enter lightly into surrogacy, or choose it for convenience, or to maintain a figure: “I don’t think anyone who wanted children would choose this as an option over anything else.”
But it is the ethics for the surrogate mothers and the risks of exploitation that most concern fertility experts.
Dr Gillian Lockwood, a fertility doctor and vice-chairman of the Royal College of Obstretricians and Gynaecologists’ ethics committee, believes the current British laws restricting payments are hard to justify.
In response to a national shortage of eggs and sperm donated for fertility treatment, the Human Fertilisation and Embryology Authority (HFEA) is currently consulting on proposals to raise the amount donors can be paid.
But the rules on surrogacy remain mired in controversy, and, so far, watchdogs and Parliament have shown little appetite to relax the current restrictions, which say payments should not overtake expenses.
Dr Lockwood says: “If you can pay for egg and sperm donors, it starts to look ridiculous that a woman can agree to carry a child for nine months and all they can get is a bit of money to buy a few maternity frocks. It would have made good sense to include this in the HFEA review rather than doing law on a case-by-case basis, which introduces a lot of uncertainty.”
The difficulty, as the fertility doctor acknowledges, is that, if the rates are too high, “temptations can become irrestistable for those living on the margins”.
Looking abroad, the global economy in surrogacy makes it almost impossible for “fair rates” to be set.
Since 2002, when India legalised the practice, it has become a world centre for surrogacy tourism, expected to generate £1.5 billion for the country annually by next year.
Dr Lockwood says: “If you have a woman in India with two children who she is struggling to bathe and feed, and one surrogacy arrangement means she can send them to school and build a house, is that exploitation? Renting a womb out might seem a much better option than a year of breaking rocks.”
Dr Allan Pacey, a fertility lecturer at the University of Sheffield, says the ethical issues are different but just as complex on home turf. “I worry particularly about the cases involving family members, who might feel under intense pressure to act as a surrogate. Areas like that are a great concern,” he says.
While media commentators have been in turn vitriolic and squeamish about the latest cases, with Sir Elton John accused of treating babies as the latest “must-have” accessory in an extravagant lifestyle, some religious figures express a deeper unease.
The Rt Rev Michael Nazir-Ali, the former Bishop of Rochester recently told The Sunday Telegraph of his concerns that the introduction of a “third party” into parenthood would affect the child psychologically. He also highlighted the age of Sir Elton, who turns 64 in March. “It is very important for a child’s parents to be of an age that provides the child with a fair chance of being brought up by them without unnecessary disrupution,” he said.
Naturally, where ethical commentators see an issue that is divisive and explosive, popular entertainment sees a ratings opportunity.
Barely recovered from the furore over its controverisal cot death/baby swap storyline, BBC soap opera EastEnders is reportedly planning to dramatise a surrogacy plot, involving gay characters Christian Clarke and Syed Masood.
It wouldn’t be the first time that the dramatic potential of reproductive technology had been detected. In 1946, Aldous Huxley reconsidered the futuristic satire – or prophecy – he had penned 15 years earlier.
“Technically and ideologically, we are still a long way from bottled babies,” he concluded – 32 years before the birth of Louise Brown, the world’s first test-tube baby.
And what of the rest of his brave new world? He looked again at the picture he had painted for 2540, with its widespread promiscuity and babies being decanted, hatched and then conditioned to live in a state that was almost free of emotion.
His verdict: “Today it seems quite possible that the horror may be upon us within a single century.”
By Laura Donnelly, The Telegraph
Friday, January 21, 2011
Fertility expert: IVF discount in return for eggs is exploitation
One of Britain's leading fertility experts today accused clinics of exploiting women by offering them cut-price IVF in return for their eggs.
Professor Robert Winston said that schemes where patients are encouraged to share their eggs with infertile women were wrong.
Lord Winston said: "Egg-sharing is a very bad idea and an easy way of exploiting women wanting treatment. It's a pretty devastating scenario to give eggs to someone else and that other person gets pregnant and you don't. Then 20 years later you're contacted by that child. It's shocking."
Lord Winston said he supported a change in the law to allow payments for egg donation. At present, egg donors can be compensated up to £250 but proposals published by the Human Fertilisation and Embryology Authority this week suggest they could in future be paid several thousand pounds.
The HFEA consultation also covers sperm donors, egg-sharing and the ethics of clinics offering "inducements" in return for eggs.
Peter Bowen-Simpkins, medical director of the London Women's Clinic which runs an egg-sharing scheme, said his clinic opposed payments to egg donors as they might not appreciate the health risks of fertility medication. "It's asking young people, especially students with debts, to donate and could permanently harm them," he said. "With egg-sharing, women are already undergoing IVF and know the risks."
Elaine O'Hara, 30, of Hampshire, and civil partner Suzanne, 29, started fertility treatment at the LWC last autumn. The couple, who are in the Army, are taking part in the egg-sharing scheme in return for part of their treatment costs. Ms O'Hara, an accountant, said: "I decided to donate eggs because we couldn't conceive and have a family without a (sperm) donor.
"More people would come forward if donors are paid - of course money would be an incentive. But I don't know if that guarantees the quality of eggs. It was made clear that if another women conceives with my eggs then we might get a 16-year-old contacting us. That would be exciting though."
The Government is also under pressure over the ban on paying women who act as surrogate mothers. Actress Nicole Kidman, 43, and her husband Keith Urban have revealed that they have become parents to a girl born with a surrogate mother last month. The couple are the biological parents of Faith Margaret, They already have a two-year-old daughter, Sunday Rose.
Thursday, January 20, 2011
First Genetic Test for Predicting IVF Success
A researcher at Albert Einstein College of Medicine of Yeshiva University has helped to develop the first genetic blood test for predicting the chances that in vitro fertilization (IVF) will lead to a successful pregnancy. The test, reported in the online medical journal PLoS ONE, is based on the finding that different subtypes of the FMR1 gene (also known as the fragile X mental retardation gene) in potential mothers are associated with significantly different chances of conceiving with IVF.
"This is the first evidence that a specific gene appears to be directly associated with IVF outcomes," said David Barad, M.D., associate clinical professor of epidemiology & population health and of obstetrics & gynecology and women's health at Einstein and one of the study's senior authors. Dr. Barad is also director of assisted reproduction at the Center for Human Reproduction (CHR) in New York City.
"Our research also suggests the FMR1 gene, some forms of which are known to predict premature ovarian failure, could be used to predict at what age a woman's fertility is going to start decreasing," he added.
The study also supports the belief that autoimmunity (immunity to one's own cells or tissues) plays a role in infertility -- a controversial topic among reproductive medicine specialists.
The study involved 339 female infertility patients who underwent a total of 455 IVF cycles at CHR. The researchers investigated the relationship between three different FMR1 genotypes and pregnancy outcomes and autoimmunity levels. Women with the "normal" FMR1 genotype had a 38.6 percent pregnancy rate; those with the "heterozygous-normal/high" genotype had a 31.7 percent pregnancy rate; and women found to have the "heterozygous-normal/low" genotype had a 22.2 percent pregnancy rate.
The genotype associated with the lowest pregnancy rate (heterozygous-normal/low) was also associated with increased measures of autoimmunity. Women with this genotype also had a higher incidence of polycystic ovary syndrome (a common cause of infertility), which is thought to have an autoimmune component. "Previous studies have suggested that autoimmunity plays a role in infertility," said Dr. Barad. "Now, for the first time, we have a potential genetic mechanism that underlies several different threats to infertility."
The cost of the blood test for the FMR1 should be relatively low -- comparable to screening tests for Tay-Sachs and other genetic diseases. While the FMR1 gene test is not yet clinically available, "It's likely that the findings will lead to clinical applications in the future," said Dr. Barad.
"Any test that is proven to have predictive value for a woman's fertility would give her a heads up in terms of planning a family," he added. "For instance, if a woman planning to go to law school or medical school learns she has a certain amount of risk of losing her ovarian function before she is 35, she may choose to bank her eggs or try having children at an earlier age, rather than delay."
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