The Ramblings of a Middle Aged Fertility Physician whose life revolves around Eggs, Sperms & Embryos....
Thursday, July 22, 2010
Don't go off the edge of this pool!
If you fancy a dip in this pool, you'll need a head for heights - it's 55 storeys up.
But swimming to the edge won't be quite as risky as it looks. While the water in the infinity pool seems to end in a sheer drop, it actually spills into a catchment area where it is pumped back into the main pool. At three times the length of an Olympic pool and 650ft up, it is the largest outdoor pool in the world at that height.
It features in the impressive, boat-shaped 'SkyPark' perched atop the three towers that make up the world's most expensive hotel, the £4billion Marina Bay Sands development in Singapore.
The hotel, which has 2,560 rooms costing from £350 a night, was officially opened yesterday with a concert by Diana Ross.
The Emirates Palace Hotel in Abu Dhabi, estimated to have cost £2billion when it opened in 2004, was previously the world's most expensive hotel.
The hotel, which has 2,560 rooms costing from £350 a night, was officially opened yesterday with a concert by Diana Ross.
The Emirates Palace Hotel in Abu Dhabi, estimated to have cost £2billion when it opened in 2004, was previously the world's most expensive hotel.
The resort is set to employ 10,000 people directly and generate up to £48million each year. Entrance to the casino alone is nearly £50 a day - but an average of 25,000 people have visited the casino daily since its initial phased opening two months ago.
Thomas Arasi, president and chief executive officer of the resort, said he expects to attract an astonishing 70,000 visitors a day, 18 million a year.
The resort was designed by Moshe Safdie, who said he based it on a deck of cards.
It was due to open in 2009, but was delayed thanks to labour and material shortages, and funding problems due to the global financial crisis.
Last night, singing legend Diana Ross performed for 2,500 VIPs in the resort's Grand Ballroom. Singer Kelly Rowland also headlined an outdoor concert there yesterday.
The opening celebrations also featured a death-defying relay. Seven teams of three participants each scaled the three towers in succession before sprinting across the 340-metre long Sands SkyPark, where the infinity pool is located, to the finish line.
Wednesday, July 21, 2010
The Big Brass Gong
After closing time at the bar, a drunk was proudly showing off his new apartment to a couple of his friends. He led the way to his bedroom where there was a big brass gong and a mallet.
"What's up with the big brass gong?" one of his guests asked.
"It's not a gong. It's a talking clock," the drunk replied.
"A talking clock? Seriously?" asked his astonished friend.
"Yup," replied the drunk.
"How's it work?" the friend asked, squinting at it.
"Watch," the drunk replied. He picked up the mallet, gave the gong an ear-shattering pound and stepped back.
The three stood looking at one another for a moment.
Suddenly a voice on the other side of the wall screamed ...
"You asshole! It's three-fifteen in the morning!"
Tuesday, July 20, 2010
Man Tattoos his body with 220 Flags
Body Tattoos are very popular among youngsters, but a 67 years old Man from India has tattooed his whole body with 220 flags and a world map.
He is so possessed for getting into Guinness Book of World Records that he has changed his first name to Guinness.
With six tattoos of countries – Canada, Union Jack, India, USA, Cyprus and the Indian Congress Party, on his face, Guinness, who changed his name in honor of the famous record book, believes that he will complete his challenge in two years.
According to Rishi, his face will include the most important flags. He believes that if the tattoo of one flag will measure 1-inch, his head will be covered with 60 flags.
Monday, July 19, 2010
Sunday, July 18, 2010
In Assisted-Reproduction Technology, Europe Leads The World
Europe leads the world in Assisted Reproduction Technology (ART) with most cycles initiated in the region, the 26th Annual Meeting of the European Society of Human Reproduction and Embryology heard.
According to data presented by the European IVF Monitoring Group (EIM), 479,288 treatment cycles were reported in 32 European countries in 2007 . This compares globally with 142,435 cycles from the US and 56,817 cycles from Australia and New Zealand. "The number of cycles performed in many developed countries has grown by 5-10% per annum over the last 5 years," said Dr. Jacques de Mouzon, chairman of ESHRE's EIM. "The 4.5% increase we observed in Europe from 2006 to 2007 however is partly due to more clinics reporting to our database," he added.
In 28 countries where clinics reported deliveries, more than 90,000 babies were born in 2007. There were 118,667 regular IVF treatments, 246,687 intracytoplasmic sperm injection (ICSI) cycles, 74,855 frozen embryo transfer cycles (FER), 15,028 egg donor cycles (ED), 6,822 preimplantation genetic diagnosis/screening cycles (PGD/PGS) and 660 in vitro maturation cycles (IVM). "The reverse trend from IVF to ICSI continues with now 67.5% of fresh cycles using the latter technology, although the efficacy of ICSI in terms of pregnancy rates is the same as standard IVF," he added.
He pointed out that the overall rate of multiple births was very similar to the previous year with European ART twin deliveries at 20.5% and triplet deliveries at 0.8%. Most countries in Europe are now recording fewer than 1% triplet deliveries, except for Italy (2.8%), Latvia (11.1%) and Serbia (3.3%). "The good news is that since 1997, we have observed a decline from 30% to 21% in overall multiple birth rates and a fourfold reduction in triplet deliveries from 3.7% to 0.8%," he said.
Nordic countries like Denmark still have the highest availability of ART at 13,263 cycles per million of women aged 15-45. The lowest availabilities were recorded in the largest economies in Europe such as Germany (3,931), UK (3,794) and Italy (3,829). This is also mirrored in the number of infants born after ART with only 1.5% in Germany, 1.8% in the UK and 1.2% in Italy. In comparison in Denmark 4.9% of all children were born through IVF.
"In the last 11 years since the beginnings of the EIM we have seen a gradual increase of 26% to 33% of pregnancies per transfer for IVF and ICSI, from 15% to 22% for FER and from 27% to 46% for oocyte donation, and all this despite the transfer of fewer and fewer embryos," said Dr. de Mouzon.
In order to further assess the safety of ART, the EIM has initiated a major study (MART - the Morbidity in ART study), collecting data from a large series of ART children born in Scandinavia. Funded by ESHRE and the Medical Faculty of Copenhagen University, the team will analyse data from the national ART registers in Denmark, Finland, Norway and Sweden. "We estimate that we will have about 75,000 children in our database at the end. The data from Denmark and Finland are ready, the Swedish will finalise their data soon and in Norway the application to obtain these data is currently being processed," explains Prof. Anders Nyboe Andersen, past chairman of the EIM.
Due to the possibility of cross-linking ART data with data from other health registers, the researchers will be able to assess long-term morbidity in these children and compare it with appropriate control groups. "It is the long-term commitment of the EIM to expand this database to other European countries, but it will be at least a year before we can present the results to the public," Prof. Nyboe Andersen concluded.
According to data presented by the European IVF Monitoring Group (EIM), 479,288 treatment cycles were reported in 32 European countries in 2007 . This compares globally with 142,435 cycles from the US and 56,817 cycles from Australia and New Zealand. "The number of cycles performed in many developed countries has grown by 5-10% per annum over the last 5 years," said Dr. Jacques de Mouzon, chairman of ESHRE's EIM. "The 4.5% increase we observed in Europe from 2006 to 2007 however is partly due to more clinics reporting to our database," he added.
In 28 countries where clinics reported deliveries, more than 90,000 babies were born in 2007. There were 118,667 regular IVF treatments, 246,687 intracytoplasmic sperm injection (ICSI) cycles, 74,855 frozen embryo transfer cycles (FER), 15,028 egg donor cycles (ED), 6,822 preimplantation genetic diagnosis/screening cycles (PGD/PGS) and 660 in vitro maturation cycles (IVM). "The reverse trend from IVF to ICSI continues with now 67.5% of fresh cycles using the latter technology, although the efficacy of ICSI in terms of pregnancy rates is the same as standard IVF," he added.
He pointed out that the overall rate of multiple births was very similar to the previous year with European ART twin deliveries at 20.5% and triplet deliveries at 0.8%. Most countries in Europe are now recording fewer than 1% triplet deliveries, except for Italy (2.8%), Latvia (11.1%) and Serbia (3.3%). "The good news is that since 1997, we have observed a decline from 30% to 21% in overall multiple birth rates and a fourfold reduction in triplet deliveries from 3.7% to 0.8%," he said.
Nordic countries like Denmark still have the highest availability of ART at 13,263 cycles per million of women aged 15-45. The lowest availabilities were recorded in the largest economies in Europe such as Germany (3,931), UK (3,794) and Italy (3,829). This is also mirrored in the number of infants born after ART with only 1.5% in Germany, 1.8% in the UK and 1.2% in Italy. In comparison in Denmark 4.9% of all children were born through IVF.
"In the last 11 years since the beginnings of the EIM we have seen a gradual increase of 26% to 33% of pregnancies per transfer for IVF and ICSI, from 15% to 22% for FER and from 27% to 46% for oocyte donation, and all this despite the transfer of fewer and fewer embryos," said Dr. de Mouzon.
In order to further assess the safety of ART, the EIM has initiated a major study (MART - the Morbidity in ART study), collecting data from a large series of ART children born in Scandinavia. Funded by ESHRE and the Medical Faculty of Copenhagen University, the team will analyse data from the national ART registers in Denmark, Finland, Norway and Sweden. "We estimate that we will have about 75,000 children in our database at the end. The data from Denmark and Finland are ready, the Swedish will finalise their data soon and in Norway the application to obtain these data is currently being processed," explains Prof. Anders Nyboe Andersen, past chairman of the EIM.
Due to the possibility of cross-linking ART data with data from other health registers, the researchers will be able to assess long-term morbidity in these children and compare it with appropriate control groups. "It is the long-term commitment of the EIM to expand this database to other European countries, but it will be at least a year before we can present the results to the public," Prof. Nyboe Andersen concluded.
Saturday, July 17, 2010
New Measurement of Telomere DNA Could Help Identify Most Viable Embryos for IVF
Scientists from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust, are the first to directly measure a specific region of DNA in human embryos. The length of this region could be a quality marker for embryonic development.
Researchers at the University of Warwick's Warwick Medical School and University Hospital, Coventry, have measured telomeres, regions of repetitive DNA at the ends of a chromosome which protect it from deterioration. Telomeres shorten each time a cell divides and when telomere length becomes critically short, the cells die.
The research, published in Molecular Human Reproduction Journal, suggests that telomere length is shortest in the early stages of an embryo's development, at around two days, and then lengthens just before implantation in the womb at five days. This lengthening may be essential for normal development, because short telomeres may not be enough to survive the many rounds of cell division that take place as embryos grow.
Lead authors Professor Geraldine Hartshorne, from the University of Warwick's Warwick Medical School, and Sarah Turner, from University Hospital , Coventry, said this discovery could have implications for IVF treatment. Professor Hartshorne said: "It has already been shown that artificially shortened telomeres cause problems in animal embryos. Human embryos are highly variable, and many of them cannot develop normally. We think that telomere length might one day be used to help diagnose which are the most viable embryos. We also know that telomeres shorten with oxidative stress, so telomere length might also provide a measure of the stressfulness of the culture systems that we use in IVF and their impact on embryos."
The research project used oocytes and embryos donated by patients undergoing IVF treatment. Only material that could not be used for the patients' own treatment was accessed for research. Sarah Turner said: These results have given us plenty of new questions as well as answers. We now need to find out why telomere length is relatively short in early development. Our next steps are looking at single sperm and eggs to work out where the telomere length in early embryos is coming from. "
Priceless!
Most Syrians struggle to even read Arabic, much less have a clue about English.
So,how do a group of Syrian protest leaders create the most impact with their signs by having the standard "Death To Americans"slogans printed in English?
Answer: They simply hire an English-speaking civilian to translate and write their statements into English.
Unfortunately, in this case, they were unaware that the "civilian" Insurance company employee hired for the job was a retired US Army Sergeant! Obviously, pictures of this protest rally never made their way to Arab TV networks,
but the results were PRICELESS!
So,how do a group of Syrian protest leaders create the most impact with their signs by having the standard "Death To Americans"slogans printed in English?
Answer: They simply hire an English-speaking civilian to translate and write their statements into English.
Unfortunately, in this case, they were unaware that the "civilian" Insurance company employee hired for the job was a retired US Army Sergeant! Obviously, pictures of this protest rally never made their way to Arab TV networks,
but the results were PRICELESS!
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