Meet the frozen sperm siblings born 15 years after their father was left infertile from cancer

As a family photograph, it is hardly out of the ordinary - two-year-old Mariella hugs her baby brother Herbie.

Yet for parents Ian and Alison Morris, it is a reminder that these are the children they never thought they could have.

Mariella and seven-month-old Herbie were born using Mr Morris's frozen sperm, stored for an astonishing 13 years after cancer treatment left him infertile.

Following his successful battle against the disease, the couple had several unsuccessful attempts at starting a family using IVF and were close to giving up in despair.

But one final try, in February 2007, worked and Mariella was born the following October.

Incredibly, the couple then had a second success last year with Herbie, by which time Mr Morris's sperm had been frozen for 15 years.

Mrs Morris, 37, said: 'I thought I'd never be a mum so to have our two miracle frozen babies really is the most wonderful thing.'

Mr Morris, 49, a design engineer, was diagnosed with chronic myeloid leukaemia in March 1994, three years after the couple married.

His wife, a buyer for a television shopping channel, said: 'We were just so shocked. The level of cancer in cells in his body was so high that the doctors said they were amazed he was still standing.'

Fortunately, Mr Morris's brother Barry was the perfect match for a life-saving bone marrow transplant.

Before the treatment, which involved chemotherapy, doctors warned him to have his sperm frozen as he would be left infertile.

After Mr Morris's recovery, the couple, of Grantham, Lincolnshire, decided to try for a family in 2002.

Mrs Morris said: 'We had been really hopeful when we had our first try at IVF as we knew there was nothing wrong with me, and we were using the frozen sperm. So when it didn't work we were devastated.'

A second and third attempt failed before they went to specialist clinic Care Fertility in Nottingham for a last try.

Mrs Morris said: 'We only had two embryos of good enough quality so we knew we didn't have much of a chance. So when I did a pregnancy test and saw the positive blue line, I just couldn't believe my eyes.

'I went for a scan at six weeks... when I saw the tiny heartbeat on the screen I just burst into tears.'

The record for a live birth from frozen sperm is 21 years, in Manchester in 2002.

Girl born a record 22 years after father's sperm is frozen

A former leukaemia patient who had his sperm frozen as a teenager has fathered a baby after doctors successfully thawed his sample a record 22 years later.

Chris Biblis was 16 when doctors told him that he needed radiotherapy that would leave him sterile and recommended before going ahead with the life-saving treatment that they put a sample of his sperm into cryogenic storage for future use.

Now aged 38, he is celebrating the birth of a healthy baby daughter, Stella, who was conceived after scientists injected a defrosted sperm into an egg from his wife, Melodie, and implanted it in her uterus.

The 22-year lapse between storage in April 1986 and conception in June 2008 is a world record, according to specialists at the US fertility clinic who carried out the procedure.

The 5lb 12oz girl was born to Mrs Lesley Brown, 29, by ceasarean section just before midnight

“From my life being saved to being able to create a life, words just can’t describe where we are now,” said Mr Biblis, of Charlotte, North Carolina, who has been free of leukaemia since the age of 18.

“I’ve got this bundle of joy to appreciate. It’s truly a miracle,” he told ABC News.

The case is being hailed as an illustration of how far infertility treatment has advanced in the past two decades and proof that sperm can remain viable for decades if they are preserved in liquid nitrogen. The previous record was 21 years.

The procedure used to create Stella did not even exist when Mr Biblis gave the sample in 1986 during his six-year struggle against leukaemia.

“I was trying to get through high school and, you know, living one day at a time just hoping I was going to make it,” he said.

It was not until 1992 that the method of intracytoplasmic sperm injection (ICSI) – by which scientists carefully select a healthy sperm cell and insert it into an egg in the laboratory – was successfully pioneered.

The technique carries an increased chance of conception beyond conventional IVF procedures, in which sperm and eggs are mixed in the laboratory to fertilise spontaneously, and was used because only 35 per cent of Mr Biblis’s sperm cells were deemed viable after thawing.

Doctors selected the best of the remaining cells and injected them into ten eggs harvested from Mrs Biblis, of which seven fertilised successfully in the laboratory. Two of the embryos were implanted, though only one survived, and five remain in storage, allowing the couple the option of having more children.

“They achieved pregnancy on their first cycle of ICSI . . . We had every reason to expect a perfect baby but are thrilled nonetheless,” said Richard Wing, a fertility specialist and founder of Reproductive Endocrinology Associates of Charlotte: “I had no concern about working with old sperm – bovine and equine sperm has been frozen for long periods and has resulted in successful gestations.”

Ice, ice, baby!

A couple from Stockport, Greater Manchester, have conceived a second baby using sperm frozen 19 years ago. Emmanuel and Zoe Iyoha are expecting their second child after receiving IVF treatment using sperm preserved on Mr Iyoha's behalf in 1989.
Mr Iyoha was diagnosed with non-Hodgkin's lymphoma and a tumour on his spleen when he was 27 years old. Staff at the Christie Hospital in Manchester warned him that the chemotherapy would leave him infertile and encouraged him to have his sperm frozen so that he would have the option of having children after he recovered. Mr Iyoha expressed his gratitude,
saying: 'it was the Christie nurses who persuaded me it was something that I should do and I will be forever grateful to them for this miracle. They must have seen within me the father-in-waiting. At the time, I was far more preoccupied with the cancer'.
Mr Iyoha, a computer expert for the NHS, has had a long battle with his cancer, but is now in remission after suffering a relapse in 1995. He married Zoe, a teacher, in 2002 and the newly-wed couple were only able to consider having children together thanks to the sperm stored at St Mary's Hospital in Manchester. 'We're certainly pretty unlikely to have an unplanned pregnancy after two bouts of chemotherapy' commented My Iyoha.
Freezing sperm is the only chance many men who face chemotherapy at a young age have of preserving their fertility. Unfortunately, however, the technique does not always work, as the sperm may be left too damaged by the freezing and thawing process for IVF to be successful. It took Mr and Mrs Iyoha 12 rounds of IVF treatment including, sadly, one miscarriage before their first child, Poppy Rose, was born in 2006. Remarkably, they have conceived their second child, which is due in July, after just four rounds of IVF.
Mr Iyoha said: 'every time I think about how long it has been since my sperm was frozen I am amazed at the power of science'. He added: 'we owe it all to science and the wonderful care and support of the staff at Christie's and St. Mary's'. In 2004, doctors at St Mary's hospital reported the birth of baby conceived using sperm that had been frozen for 21 years, believed to
be the longest reported storage period for sperm successfully used for treatment.