The Ramblings of a Middle Aged Fertility Physician whose life revolves around Eggs, Sperms & Embryos....
Sunday, August 24, 2008
The Portofino at Lavasa
Happiness is like the common cold -- it's catching!
-Anonymous
Portofino (Ligurian: Portofin) is a small Italian fishing village, comune and tourist resort located in the province of Genoa on the Italian Riviera. The town crowded round its small harbour is considered to be among the most beautiful Mediterranean ports. The residents of Portofin would never in their wildest dreams imagine a sister-town in this part of the world and what -a-sister!!! Lavasa is located at an altitude of 2000-3000 feet above sea level, with state-of-the-art roads, robust infrastructure and a salubrious climate all year round. It is the largest Hill Station to be planned and developed using the Geographical Information System (GIS).Through GIS, accurate information will be provided to its facility managers anywhere in the world regarding the status of the Hill Station. At Lavasa, utmost care is taken to provide world-class amenities for its citizens. A well laid out Hill Station with facilities on par with the world, Lavasa uses the best of technology to preserve the ecosystem, yet having all the modern amenities. State-of-the-art roads, Convention Center, health and wellness center, international standard golf course coupled with landscaped gardens and parks are just some of the amenities which we will enjoy at Lavasa. Based on the principles of New Urbanism, Lavasa is free India’s largest Hill Station. Lakeside promenade with open air cafés, town hall for cultural activities, world-class educational institutions which will cater to all communities etc are well planned out according to its award winning Master Plan. A far escape from the noise and chaos of the big cities, Lavasa is a complete world in itself. The lakeside homes enveloped inside the natural surroundings of the mountains are replete with all the modern amenities. Workplace cocooned in the pristine valley, yet connected globally gives people an opportunity to explore a whole new work culture. A hub for world-class educational institutions, hospitality and training centers, it's an arena for the mind where learning is a way of life. A refreshing climate with vast open spaces provides innumerable recreation and leisure activities like golf, trekking, rappelling…to satiate the adventurer in you. Nature trails have been mapped with GPS and points of interest are described. A significant contribution has been made towards trail guides highlighting the rich diversity of flora and fauna at Lavasa.The canvas is huge; the picture is detailed to perfection. Nestled comfortably in the heart of Mose valley, homes at Lavasa are inspired by the water confluence. The unique topography of the valley with its serene lake is one of the most influencing factors in the design of homes at Dasve. The Master Plan of Dasve has won an international award for its design and adaptability. Lakeside apartments and spacious villas embracing the valley are influenced by the Goan and Mediterranean architecture. The lakeside promenade is dotted with elegant cafés and restaurants where residents of Lavasa can enjoy urban lifestyle close to nature. Already the first couple of stores on the promenade are functional & a multicuisine fusion restaurant should be functional before Diwali. I seem to be possesed by this state of happiness when I get past the Lavasa Dwaar or the town gate. I thought it was only me, but I have taken enough blind tests of friends and family and let me assure you that happiness at Lavasa is contagious.
Today, let me not talk about my feelings. This blog will be on the technical stuff I picked up at the Lavasa introductory lecture & their brochure stuff! The pictures are exclusively mine, though! The Portofino area in the first phase(Dasve phase) of the HCC master plan should be completely ready and populated by late 2010. Setting new benchmarks in construction, planning and service delivery Lavasa offers its residents a level of town infrastructure hitherto, unknown in India. The high quality roads to Lavasa would provide total connectivity to its residents and visitors. Lavasa is approached by various routes. World-class road from the Chandni Chowk (Pune) to Lavasa makes traveling speedy and comfortable. At Lavasa, water is supplied from the lake to a Water Treatment Plant which is designed to meet all the current international health standards. This ultra modern Water Treatment Plant is built in Dasve to cater the need of potable water. The water supply system that meets the European health standards, provides world-class quality and purity of water. An advanced Sewage Treatment System has been setup at Lavasa. The Central Sewage Treatment Plant is based on extended aeration process with tertiary treatment so as to achieve the best quality of treated water. Building on the network of fibre optic cables, infrastructure exists today to provide the highest levels of bandwidth across voice, data and or video requirements. Coupled with the citywide GIS system, the system is designed to maintain Lavasa's technology leadership position, while providing the wow factor to technophiles and techno-phobic alike. Ensuring continued harmony with nature, numerous technologies including biomethanation, pyrolysis, controlled aerobic composting, sanitary landfills and pellatisation have been employed to mitigate the impact on the environment. The entire area of Dasve is covered by a natural drainage network of shallow and deep-water streams and channels. The natural runoff from the hills has been enhanced with a well-developed storm water system. To retain the flow of natural water, culverts of adequate sizes are provided at every crossing of road and stream so that the natural drainage of the area is unchanged.
The Dasve Lake which is designed to provide sporting and recreational facilities is enhanced by a 2.4 kms promenade which once completed, will form part of the retail and entertainment hub at Lavasa. With arbours, pedestrian bridges, shopping enclaves and dining areas, this will be the heart of Dasve. Imagine a home nestled in a picturesque valley, where the tranquil old world blends seamlessly with the cosmopolitan way of life. Lavasa offers a vibrant, self-contained world which is part of 25,000 hectares of land declared as Hill Station with an extensive Master Plan covering one third that area. The rest of the region is left untouched to preserve the natural beauty. Envisioned as a complete Hill Station offering a balanced life in harmony with nature, Lavasa is an aspirational destination for lifestyle seekers. Based on the principles of New Urbanism, the Master Plan of Lavasa has been developed by internationally renowned design consultant HOK, USA.
The philosophy behind housing at Lavasa is to create comfortable homes for people using the best of technology, for an elegant lifestyle. Lavasa is the sure-fire recipe for happiness- this coming from a doctor-believe me!
How simple and frugal a thing is happiness: a glass of wine, a roast chestnut, a wretched little brazier, the sound of the sea. . ....All that is required to feel that here and now is happiness is a simple, frugal heart.
- Nikos Kazantzakis, Zorba the Greek
Saturday, August 23, 2008
The Polish Divorce
A Polish man moved to the USA and married an American girl..
Although his English was far from perfect, and they got along very well.
One day he rushed into a lawyer's office and asked him if he could arrange a divorce for him.
The lawyer said that getting a divorce would depend on the circumstances, and asked him the following questions:
Have you any grounds?
Yes, an acre and half and nice little home.
No, I mean what is the foundation of this case?
It made of concrete.
I don't think you understand. Does either of you have a real grudge?
No, we have carport, and not need one.
I mean. What are your relations like?
All my relations still in Poland .
Is there any infidelity in your marriage?
We have hi-fidelity stereo and good DVD player.
Does your wife beat you up?
No, I always up before her.
Is your wife a nagger?
No, she white.
Why do you want this divorce?
She going to kill me.
What makes you think that?
I got proof.
What kind of proof?
She going to poison me. She buy a bottle at drugstore and put on shelf in bathroom. I can read, and it say: 'Polish Remover'
Although his English was far from perfect, and they got along very well.
One day he rushed into a lawyer's office and asked him if he could arrange a divorce for him.
The lawyer said that getting a divorce would depend on the circumstances, and asked him the following questions:
Have you any grounds?
Yes, an acre and half and nice little home.
No, I mean what is the foundation of this case?
It made of concrete.
I don't think you understand. Does either of you have a real grudge?
No, we have carport, and not need one.
I mean. What are your relations like?
All my relations still in Poland .
Is there any infidelity in your marriage?
We have hi-fidelity stereo and good DVD player.
Does your wife beat you up?
No, I always up before her.
Is your wife a nagger?
No, she white.
Why do you want this divorce?
She going to kill me.
What makes you think that?
I got proof.
What kind of proof?
She going to poison me. She buy a bottle at drugstore and put on shelf in bathroom. I can read, and it say: 'Polish Remover'
Friday, August 22, 2008
The Speeding Fisherman
This is an actual emergency room photo of a fisherman who lost control of his high-speed bass boat in West Virginia . Wardens believe that he was travelling at a speed of approximately 75 MPH at the time of the accident. He was unable to negotiate a curve in the narrow waterway.
Unfortunately for him, upon striking the shoreline and being ejected from the boat, he landed back end first on an old fence post.
You can probably picture what happened next, but the attached picture really says it all. The good news is that after about 6 months, this man made a full recovery after suffering a shattered hip, broken leg, several broken ribs, internal injuries and soft tissue damage. Doctors credited his recovery to the fact that the post lodged itself so tightly that there was little or no blood loss.
Now that's got to hurt!!!
Moral of the story is DON'T DRIVE THAT FISHING BOAT TOO FAST!!!!!
Now look at the photo! BRACE YOURSELF 1ST THOUGH!!!
Thursday, August 21, 2008
Breast cancer recurrence not increased with controlled ovarian stimulation
Ovarian stimulation using gonadotropins and letrozole to preserve fertility in patients with breast cancer undergoing chemotherapy is unlikely to increase their risk for recurrence, say US researchers.
Kutluk Oktay, from the Center for Human Reproduction in New York, and colleagues evaluated 215 women with breast cancer for fertility preservation before adjuvant chemotherapy. Overall, 79 of the women underwent controlled ovarian stimulation (COS) for embryo or oocyte preservation, while the remainder served as controls.
An average of 10.3 oocytes were retrieved from COS patients, with 5.97 embryos or oocytes cryopreserved per patient.
The time between surgery and chemotherapy was significantly longer for patients who underwent IVF than control patients, at 45.08 versus 33.46 days. In patients who had COS, peak estradiol levels ranged from 58.4 to 1,166 pg/ml.
In the COS group, median follow-up after chemotherapy was 23.4 months, compared with 33.05 months in the control group. Recurrence occurred in 3.8 and 8.1 percent of COS and control patients, respectively, at a nonsignificant hazard ratio of 0.56.
The team concludes: "COS before embryo or oocyte cryopreservation is unlikely to result in a significant increase in recurrence of breast cancer compared with those who did not undergo ovarian stimulation, at least in the short term."
Kutluk Oktay, from the Center for Human Reproduction in New York, and colleagues evaluated 215 women with breast cancer for fertility preservation before adjuvant chemotherapy. Overall, 79 of the women underwent controlled ovarian stimulation (COS) for embryo or oocyte preservation, while the remainder served as controls.
An average of 10.3 oocytes were retrieved from COS patients, with 5.97 embryos or oocytes cryopreserved per patient.
The time between surgery and chemotherapy was significantly longer for patients who underwent IVF than control patients, at 45.08 versus 33.46 days. In patients who had COS, peak estradiol levels ranged from 58.4 to 1,166 pg/ml.
In the COS group, median follow-up after chemotherapy was 23.4 months, compared with 33.05 months in the control group. Recurrence occurred in 3.8 and 8.1 percent of COS and control patients, respectively, at a nonsignificant hazard ratio of 0.56.
The team concludes: "COS before embryo or oocyte cryopreservation is unlikely to result in a significant increase in recurrence of breast cancer compared with those who did not undergo ovarian stimulation, at least in the short term."
Wednesday, August 20, 2008
2008 Olympics Opening Ceremony
Tuesday, August 19, 2008
The Hand of Hope!
Please read before viewing picture - it's worth it!
A picture began circulating in November. It should be 'The Picture of the Year,' or perhaps, 'Picture of the Decade.' It won't be. In fact,unless you obtained a copy of the US paper which published it, you probably would never have seen it.
The picture is that of a 21-week-old unborn baby named Samuel Alexander Armas, who is being operated on by surgeon named Joseph Bruner.
The baby was diagnosed with spina bifida and would not survive if removed from his mother's womb. Little Samuel's mother, Julie Armas, is an obstetrics nurse in Atlanta. She knew of Dr. Bruner's remarkable surgical procedure. Practicing at Vanderbilt University Medical Center in Nashville , he performs these special operations while the baby is still in the womb.
During the procedure, the doctor removes the uterus via C-section and makes a small incision to operate on the baby. As Dr.Bruner completed the surgery on Samuel, the little guy reached his tiny, but fully developed hand through the incision and firmly grasped the surgeon's finger. Dr..Bruner was reported as saying that when his finger was grasped, it was the most emotional moment of his life, and that for an instant during the procedure he was just frozen, totally immobile.
The photograph captures this amazing event with perfect clarity. The editors titled the picture, 'Hand of Hope.' The text explaining the picture begins, 'The tiny hand of 21-week- old fetus Samuel Alexander Armas emerges from the mother's uterus to grasp the finger of Dr. Joseph Bruner as if thanking the doctor for the gift of life.'
Little Samuel's mother said they 'wept for days' when they saw the picture. She said, 'The photo reminds us pregnancy isn't about disability or an illness, it's about a little person.' Samuel was born in perfect health, the operation 100 percent successful.
Now see the actual picture, and how awesome and completely incredible it is! The world needs to see this one!
Monday, August 18, 2008
Scientists identify possible cause of endometriosis
Endometriosis is a condition whereby patches of the inner lining of the womb appear in parts of the body other than the womb cavity. It can cause severe pain and affects approximately 15% of women of reproductive age. Endometriosis is also associated with infertility, with 50% of infertile women affected by the condition.
Researchers discovered that an enzyme, called telomerase, is released by cells in the inner lining of the womb during the latter stages of the menstrual cycle in women who are affected by endometriosis. Telomerase is not commonly found in the cells that make up the body, but is uniquely found in the inner lining of the womb and in some special cells, such as sperm and egg cells. The enzyme is also found in cancer cells and is thought to be responsible for replicating DNA sequences during cell division in chromosomes.
Dr Dharani Hapangama, from the University's Department of Reproductive and Developmental Medicine, explains: "Endometriosis occurs when cells of the inner lining of the womb are found growing outside of the uterus. At the time of a woman's menstruation cycle these cells, called endometrial cells, are shed and can be expelled into the abdominal cavity. If these cells continue to live and are implanted in the pelvis and abdomen it can cause severe pain and in serious cases can lead to infertility.
"We found the telomere – a region at the end of all chromosomes that prevents the chromosome destroying itself during cell division – is abnormally long in women with endometriosis. During menstruation telomeres normally shorten in length with each cycle of cell division until they reach a certain length at which they can no longer divide. An enzyme called telomerase can extend the length of the telomeres so that they can continue to divide and this can happen in some special cells such as sperm and egg cells, but not normally in cells that make up the organs of the body.
"Our research shows, however, that cells in the lining of the womb are unique in that they can express this enzyme in the early stages of the menstrual cycle when cell division is important, but not during the latter stages when implantation of the fertilised embryo becomes a priority.
"Women who have endometriosis express this enzyme in both the early and late stages of the menstrual cycle which means that the cells will continue to divide and lose their 'focus' in supporting the establishment of a pregnancy. As a result the lining of the womb may be more hostile to an early pregnancy, and the cells that are shed at this late stage in the menstrual cycle may be more 'aggressive' and more able to survive and implant outside the uterus, causing pain in the pelvic or abdomen area."
The research, published in Human Reproduction, will help scientists develop new techniques for diagnosing and treating the condition.
Researchers discovered that an enzyme, called telomerase, is released by cells in the inner lining of the womb during the latter stages of the menstrual cycle in women who are affected by endometriosis. Telomerase is not commonly found in the cells that make up the body, but is uniquely found in the inner lining of the womb and in some special cells, such as sperm and egg cells. The enzyme is also found in cancer cells and is thought to be responsible for replicating DNA sequences during cell division in chromosomes.
Dr Dharani Hapangama, from the University's Department of Reproductive and Developmental Medicine, explains: "Endometriosis occurs when cells of the inner lining of the womb are found growing outside of the uterus. At the time of a woman's menstruation cycle these cells, called endometrial cells, are shed and can be expelled into the abdominal cavity. If these cells continue to live and are implanted in the pelvis and abdomen it can cause severe pain and in serious cases can lead to infertility.
"We found the telomere – a region at the end of all chromosomes that prevents the chromosome destroying itself during cell division – is abnormally long in women with endometriosis. During menstruation telomeres normally shorten in length with each cycle of cell division until they reach a certain length at which they can no longer divide. An enzyme called telomerase can extend the length of the telomeres so that they can continue to divide and this can happen in some special cells such as sperm and egg cells, but not normally in cells that make up the organs of the body.
"Our research shows, however, that cells in the lining of the womb are unique in that they can express this enzyme in the early stages of the menstrual cycle when cell division is important, but not during the latter stages when implantation of the fertilised embryo becomes a priority.
"Women who have endometriosis express this enzyme in both the early and late stages of the menstrual cycle which means that the cells will continue to divide and lose their 'focus' in supporting the establishment of a pregnancy. As a result the lining of the womb may be more hostile to an early pregnancy, and the cells that are shed at this late stage in the menstrual cycle may be more 'aggressive' and more able to survive and implant outside the uterus, causing pain in the pelvic or abdomen area."
The research, published in Human Reproduction, will help scientists develop new techniques for diagnosing and treating the condition.
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