The Ramblings of a Middle Aged Fertility Physician whose life revolves around Eggs, Sperms & Embryos....
Wednesday, April 8, 2009
Sushi and Sashimi
This is a true case of a Japanese man from Gifu prefecture who complains incessantly about a persistent headache. Mr. Shota Fujiwara loves his sashimi and sushi very much to the extent of trying to get them as 'alive and fresh' as can be for his insatiable appetite. He develops a severe headache for the past 3 years and has diagnosed it as migraine and stress from work. It was only when he started losing his psychomotor skills that he seeks medical help. A brain scan and x-ray reveals little however.
But upon closer inspection by a specialist on his scalp, the doctor noticed small movements beneath his skin. It was then that the doctor did a local anesthetic to his scalp and discovered the cause when tiny worms crawled out.
A major surgery was thus immediately called for and the extent of the infestation was horrific. See the attached pictures to the scene that one thought only a movie could produce.
Remember, tapeworms and roundworms and their eggs which abound in all fish- fresh or salt-water fish can only be killed by thorough cooking and/or freezing the fish to between 4 deg C - 0 deg C. The eggs of these parasites can only be killed if it is cooked or frozen to the said temperatures for a week or more.
Think twice about that raw dish next time...or you might get a headache.
Tuesday, April 7, 2009
Flamingos and The Sewri Fort
The Sewri Fort (also spelled Sewree Fort) (Marathi: शिवडी किल्ला) is a fort in Mumbai built by the British at Sewri. Built in 1680, fort served as a watch tower, atop a quarried hill overlooking the Mumbai harbor.Up to the eighteenth century, Mumbai consisted of several small islands. In 1661, seven of these islands were ceded by the Portuguese to the British as part of the dowry of Charles II of England. The harbor proved eminently apposite, and the British planned to shift base from Surat to Mumbai. The Siddis, who were of African descent and noted for their navies, had allied themselves with the Mughals. The British, under the East India Company and the Mughals were constantly waged war on each other. As allies of the Mughals, the Siddis also declared the British as enemies.Faced with relentless attacks by the Siddis in 1672, several fortifications were constructed in Mumbai, and in 1780 the Sewri fort was complete. It stood on the island of Parel, on a hill overlooking the eastern seaboard and Indian mainland. It had a garrison of 50 sepoys and was managed by a subedar. It was also armed with eight to ten cannons.
How would Mumbai look today if the African Siddi Yakut had captured the island city from the British in 1689? If the British hadn’t filled the coffers of Mughal Emperor Aurangzeb to end the nine-month siege of the Mazgaon fort, Mumbai’s history would have been very different.Chances are that the city would perhaps never have witnessed its transformation into the 18th century modern city and the present-day financial nerve centre.Most Mazgaon residents who frequent the amazingly clean and well-maintained civic garden atop Bhandarwada Hill for evening walks don’t know that a fort once existed on this hillock, perched above the Dockyard railway station and overlooking P D’Mello Road. Nor do the elders who frequent a shelter created for senior citizens in the garden.But, Suman Tate with Bhau Daji Laud Museum, Byculla, however, confirms that Bhandarkar Hill was the place where the Mazgaon fort stood. ‘‘After the Siddis captured the Sewri fort, they attacked the Mazgaon fort. I came across references to a battle between Chhatrapati Shivaji’s son Sambhaji and Siddi Yakut on this fort, but that needs to be confirmed. I even remember seeing a cannon there several years ago,’’ says Tate, who is engaged in a research project on Mumbai’s forts.The Bombay Gazetteer, a highly detailed account of the city by the British, provides a fascinating glimpse into the strategic location of the Sewri Fort and the ferocity of the invasions by the Siddis, the generals of North African origin who worked with Mughal Emperor Aurangzeb. The Siddis repeatedly attacked the islands in Mumbai harbour from 1672, at a time when the British had acquired the island city from the Portuguese but were yet to shift their trading headquarters from Surat to Mumbai. The increasing invasions by the Siddi fleets were one of the reasons why the East India Company finally moved its base to secure the Mumbai harbour.There are references to show that the Siddis terrorised Mumbai’s natives; they drove people from their houses, pillaged and burnt their homes, adorned the heads of massacred Marathas on poles along the Mazgaon shore, and sold Maratha captives in the town market.According to the Gazetteer, the most ambitious of Siddi invasions was in 1689, when Siddi Yakut, backed by 20,000 men, stormed Mumbai. The fleet first captured the Sewri fort, plundered Mahim town, and moved towards Mazgaon. The news that the Siddis had arrived at Sewri frightened Mazgaon the ‘‘natives’’ so much that they abandoned the fort.Despite British Governor Sir John Child’s attempt to dislodge the Siddi, he had captured virtually the whole of the island city except the fortified British garrison in South Mumbai. The Siddi siege, from April to December of 1689, forced the British to survive on stocked food, and eventually strike a deal with Aurangzeb to get rid of him.The Gazetteer notes that in December, Child despatched envoys to Aurangzeb to buy peace. In February, 1690, the Mughal emperor issued an order agreeing to withdraw the Siddi fleet if the British paid Rs 1.5 lakh and sacked Child as governor.Siddi Yakut eventually withdrew his forces on June 8, 1690, but before leaving Mazgaon, he burnt and destroyed the fort in a single act of defiance.After the decline of the regional powers, the fort was subsequently used to house prisoners. It was later converted as a Bombay Port Trust godown.
The fort was built primarily for defence, and embellishments are absent. It is bordered by high stone walls, including an inner ring for added protection. It is landlocked on three sides, and sits atop of sheer cliff of about 60 m (197 ft).Today it is in a pitiable state, just like other heritage monuments in Mumbai:(( The plight of these monuments is not solely due to the neglect of the authorities but also due to the indifference of the elite. Since we cannot depend on the authorities, who are always short on money and imagination, it is the people who should take the initiative to preserve these structures.
The Sewri Fort is currently owned by Maharashtra state's Department of Archaeology and Museums. It is classified as a Grade I heritage structure, and efforts are underway under Phase I of Mumbai Fort Circuit Project to restore it.The restoration involves the creation of two zones. Zone I includes the immediate fort area. The crumbling walls are to be repaired, debris cleared off, roofs rebuilt, steps fixed and a garden created in the complex. A museum is also to be constructed. Zone II renovation consists of the surrounding areas that belong to the Mumbai Port Trust. In this, a sea-facing promenade is to be created that links the fort to the waterfront, along with the creation of a landscaped garden, food court, and amphitheater. The total cost for this project estimated in 2008 is Rs. 3.65 crore (US$ 732,000).The strategic location of the fort would also promote ornithology as the area overlooks the Sewree mudflats, that are frequented by migratory birds, particularly the lesser flamingos. Mumbai is never short when it comes to surprises. One of the surprises is the arrival of beautiful flamingos in this highly polluted and crowded metropolis. Currently these flamingos are in the news as plans for the construction of the Sewri-Navi Mumbai bridge are taking shape. Environmentalists are voicing their concerns as they see a total destruction of this habitat.The huge expanse of colorless mud flats in Sewri glow with the arrival of countless pink lesser flamingos. For 6 months this area gets a look of an exotic bird sanctuary. They are coming to Mumbai since the early 90s and stay on these mudflats from October to April/May.
Nearly 10,000 Greater Flamingos and Lesser Flamingos can now be spotted in large groups on the wet and marshy mudflats of Sewri bay.We decided to go on impulse after our Bandra-Worli sealink tour & I drove there on pure memory from our school-trip!‘‘No one knows exactly where the flamingos come from at this time of the year. Some experts feel that the birds fly here from the Rann of Kutch, where they normally breed,’’ Isaac Kehimkar, the spokesperson of Bombay Natural History Society (BNHS), said in a DNA interview.Best time to watch them is between high tide and low tide. A good pair of binoculars, a cap and patience are the only things required to make this visit a memorable experience.
Apart from flamingos, numerous other species including gulls, terns and waders can also be spotted at Sewri. Standing there on the BPT jetty,looking down at the grease stained, rocky beach with plastic bags strewn in all directions, with the heavy rumbling of the Colgate Palmolive factory behind us, we saw a distant line of light pink covering the mudflats, the pink birds eating tiny mussels and walking about like Japanese puppets in the hot sun. I needed a better vantage. Walking away from the jetty I could see the ruined Sewree Fort above so I decided to make a photo-stop at the fort. Looking down at the mud-flats, I could visually imagine the historical sea-battles for supremacy of the Mumbai harbor. I then decided that I would keep my free weekends to explore our heritage in and around Mumbai....
I came back to the jetty at 9:00am & saw serious bird watchers with their equipment. We were given impromptu lessons by an experienced bird-watcher from the UK, who let us take a close-up view with his 30X telescope. Kids, their parents & grand-parents started arriving in droves & we decided to come another day with a foldable table & have breakfast at dawn on the jetty with Flamingos as our guests. Just as we were about to return to our respective cars, we saw this diminutive local, who came in sliding from the mud-flats towards the jetty. He was carrying his catch of fresh live crabs. Twenty crabs took him all of 5 hours in the hot sun. He gave us some education about crab-catching & also tales about the mud-skippers!!!(seen in my photograph).We saw these "skipping" fish all over the mud-flats. Mudskippers are completely amphibious fish, uniquely adapted to intertidal habitats, unlike most fish in such habitats, which survive the retreat of the tide by hiding under wet seaweed or in tidal pools. Mudskippers are quite active when out of water, feeding and interacting with one another, for example to defend their territories.Compared with fully aquatic gobies, these fish present a range of peculiar behavioral and physiological adaptations to an amphibious lifestyle. These include anatomical and behavioral adaptations that allow them to move effectively on land as well as in the water. As their name implies these fish use their fins to move around in a series of skips. They can also flip their muscular body to catapult themselves up to 60 cm into the air. We were amazed by their acrobatics & there were serious fish watchers video-filming these jumps & flips!!!
What an amazing and memorable Sunday morning!
Monday, April 6, 2009
Sunday, April 5, 2009
Saturday, April 4, 2009
Hello... am I speaking with India??
These answers are the actual responses to the questions on a Indie-Travel website posted by those who are planning a visit to India.
Q:Does it ever get windy in India ? I have never seen it rain on TV, how do the plants grow?(someone from UK ).
A:We import all plants fully grown and then just sit around watching them die.
Q:Will I be able to see elephants in the street? ( USA )
A:Depends how much you've been drinking.
Q:I want to walk from Delhi to Goa - can I follow the railroad tracks? ( Sweden )
A:Sure, it's only three thousand kms, take lots of water.
Q:Is it safe to run around in the bushes in India ? ( Sweden )
A:So it's true what they say about Swedes.
Q:Are there any ATMs (cash machines) in India ? Can you send me a list of them in Delhi , Chennai, Calcutta and Bangalore ? ( UK )
A:What did your last slave die of?
Q:Can you give me some information about hippo racing in India ? ( USA )
A:A-fri-ca is the big triangle shaped continent south of Europe . In-di-a is that big triangle in the middle of the Pacific & Indian Ocean which does not.. oh forget it. ...... Sure, the hippo racing is every Tuesday night in Goa.Come naked.
Q:Which direction is North in India ? ( USA )
A:Face south and then turn 180 degrees. Contact us when you get here and we'll send the rest of the directions.
Q:Can I bring cutlery into India ? ( UK )
A:Why? Just use your fingers like we do.
Q:Can you send me the Indiana Pacers matches schedule? ( France )
A:Indiana is a state in the Unites States of...oh forget it. Sure, the Indiana Pacers matches are played every Tuesday night in Goa , straight after the hippo races. Come naked.
Q:Can I wear high heels in India ? ( UK )
A:You're a British politician, right?
Q:Are there supermarkets in Bangalore , and is milk available all year round? (Germany)
A:No, we are a peaceful civilization of vegan hunter/gatherers. Milk is illegal.
Q:Please send a list of all doctors in India who can dispense rattlesnake serum. (USA)
A:Rattlesnakes live in A-meri-ca which is where YOU come from. Most Indian snakes are perfectly harmless, can be safely handled and make good pets.
Q:Do you have perfume in India ? ( France )
A:No, actually we don't stink.
Q:I have developed a new product that is the fountain of youth. Can you tell me where I can sell it in India ?(USA )
A:Anywhere ...where a significant numbers of Americans like you gather.
Q:Do you celebrate Christmas in India ? ( France )
A:Only at Christmas.
Q:Will I be able to speak English most places I go? ( USA )
A:Yes, but you'll have to learn it first.
Q:Can I see Taj Mahal anytime? ( Italy )
A:As long as you are not blind, you can see it anytime.
Q:Do you have Toilet paper? ( USA )
A:No, we use sand paper. (we have different grades)
Q:Does it ever get windy in India ? I have never seen it rain on TV, how do the plants grow?(someone from UK ).
A:We import all plants fully grown and then just sit around watching them die.
Q:Will I be able to see elephants in the street? ( USA )
A:Depends how much you've been drinking.
Q:I want to walk from Delhi to Goa - can I follow the railroad tracks? ( Sweden )
A:Sure, it's only three thousand kms, take lots of water.
Q:Is it safe to run around in the bushes in India ? ( Sweden )
A:So it's true what they say about Swedes.
Q:Are there any ATMs (cash machines) in India ? Can you send me a list of them in Delhi , Chennai, Calcutta and Bangalore ? ( UK )
A:What did your last slave die of?
Q:Can you give me some information about hippo racing in India ? ( USA )
A:A-fri-ca is the big triangle shaped continent south of Europe . In-di-a is that big triangle in the middle of the Pacific & Indian Ocean which does not.. oh forget it. ...... Sure, the hippo racing is every Tuesday night in Goa.Come naked.
Q:Which direction is North in India ? ( USA )
A:Face south and then turn 180 degrees. Contact us when you get here and we'll send the rest of the directions.
Q:Can I bring cutlery into India ? ( UK )
A:Why? Just use your fingers like we do.
Q:Can you send me the Indiana Pacers matches schedule? ( France )
A:Indiana is a state in the Unites States of...oh forget it. Sure, the Indiana Pacers matches are played every Tuesday night in Goa , straight after the hippo races. Come naked.
Q:Can I wear high heels in India ? ( UK )
A:You're a British politician, right?
Q:Are there supermarkets in Bangalore , and is milk available all year round? (Germany)
A:No, we are a peaceful civilization of vegan hunter/gatherers. Milk is illegal.
Q:Please send a list of all doctors in India who can dispense rattlesnake serum. (USA)
A:Rattlesnakes live in A-meri-ca which is where YOU come from. Most Indian snakes are perfectly harmless, can be safely handled and make good pets.
Q:Do you have perfume in India ? ( France )
A:No, actually we don't stink.
Q:I have developed a new product that is the fountain of youth. Can you tell me where I can sell it in India ?(USA )
A:Anywhere ...where a significant numbers of Americans like you gather.
Q:Do you celebrate Christmas in India ? ( France )
A:Only at Christmas.
Q:Will I be able to speak English most places I go? ( USA )
A:Yes, but you'll have to learn it first.
Q:Can I see Taj Mahal anytime? ( Italy )
A:As long as you are not blind, you can see it anytime.
Q:Do you have Toilet paper? ( USA )
A:No, we use sand paper. (we have different grades)
Friday, April 3, 2009
A Beautiful Dawn in Lavasa
What can I say, everyday I greet you with a cool smile but you seldom notice. I am taken for granted by billions and only appreciated by a few. Every morning I look forward to greeting you looking my best but you never notice. Past generations greeted me with a smile and took the time to appreciate my beauty. In some cultures the first born was named in my honor. Those were much simpler times. Today you are in such a hurry that I feel I am a nuisance and not a blessing as you rinse the dew I left on your car. As I arrive every morning millions of animals greet me with song and playfulness but you, don’t even take the time to appreciate them. I guess it is true what you say time is money, but money can never buy what you miss every morning. A song has recently written about me and I hope it will help you understand what I have been trying to say. The song goes like this:
James Blunt - High
Beautiful dawn - lights up the shore for me.
There is nothing else in the world,
I’d rather wake up and see (with you).
Beautiful dawn - I’m just chasing time again.
Thought I would die a lonely man, in endless night.
But now I’m high; running wild among all the stars above.
Sometimes it’s hard to believe you remember me.
Beautiful dawn - melt with the stars again.
Do you remember the day when my journey began?
Will you remember the end (of time)?
Beautiful dawn - You’re just blowing my mind again.
Thought I was born to endless night, until you shine.
High; running wild among all the stars above.
Sometimes it’s hard to believe you remember me.
Will you be my shoulder when I’m grey and older?
Promise me tomorrow starts with you,
Getting high; running wild among all the stars above.
Sometimes it’s hard to believe you remember me.
Here I am trapped between these two concrete walls and plated glass. Forced to serve my time away from everything I love. I had promised my kids the vacation to Disney & Universal in California & am boarding the flight in a few minutes. I will miss Lavasa for three weeks now! Anyways the last week in Mexico is dedicated to the "Sergio Bustamante" store at Lavasa due to open coming Diwali.
How often did I really think about nature? Not often! I had never really stopped or slowed down my life to think about the great and beautiful things nature has to offer. That is until I started visiting Lavasa regularly. It is now that I have come to realize the wonderful things nature in Lavasa has offered me and I have never, like they say….stopped to smell the roses! I had always been too busy with my job and life itself that I had forgotten to take a moment to embrace nature; today I miss my Lavabahn cruising as I exit my country.
The water body beautifies the hill station and everything around it. The trees make it so inviting and I remember thinking….I’m coming back here and just relax and enjoy the view. Of course, I will now not have the chance to go back for 3 weeks!!! Why don’t we appreciate nature and take advantage of what it provides us. Natural beauty is found all around. The trees seem to call out to us and invite us to take a break from our daily lives and just relax and read a book under them. They provide the shade and protection that we so much need in hot sunny days, as well as in shady, cloudy ones. Sitting on the green, crispy grass under my favorite tree near Ekaant makes me feel I can open my arms to the clear, blue sky. I can actually breathe and slow down to really observe my surroundings. The water makes the area so tranquil and soothing. The sound of the water is music to my ears. The sunlight on the Warasgaon Lake creates illusions of wonderful shapes in many different colors yet to be named.
I can see fish swimming slowly in the water and disappear in its depth. I can hear the chirping of the birds and the sound of branches as they play happily on the trees. It’s almost as watching children running joyfully. I can smell the pureness of the air and fill my lungs with the ecstatic energy that only nature can provide. Time seems to stand still as I sit here and enjoy the natural beauty of the environment. I wish I did not have to leave this enchanted place. I envy the ants that are free to come and go everywhere they want; the birds that fly all over the sky and yet always come back and the fish that live in the waterbody and know all its treasures and its most precious secrets. Daily life struggles seem to fade away and I feel empowered to conquer anything…anything at all! How wonderful is this feeling of peace, courage and happiness and to think that nature is found everywhere. Only three hours from Mumbai!
Thursday, April 2, 2009
Best Human Embryos Selected For IVF Using Mathematical Model
From the images taken with the microscope, the scientists were able to measure and classify the zygotes and embryos, as well as the blastomeres (undifferentiated animal cells produced by the division of the zygote), their degree of fragmentation and the thickness of the ‘zona pellucida', a membrane that surrounds them. (Credit: Morales et al / SINC)
A team of researchers from the University of the Basque Country (UPV-EHU) have developed a mathematical classification which makes it possible to select human embryos for use in assisted reproduction treatments. Scientists have used the morphology of embryos to select the best candidates for implantation in the woman's uterus.
"Up to now experts working in in vitro fertilisation have selected the best embryos subjectively, based on their training and experience", so SINC was informed by Dinora A. Morales, from the Intelligent Systems Group at the UPV-EHU. However, in two studies carried out by researchers from this team the use of mathematical classifiers to help embryologists with that task was looked at.
In the first work, published in the journal Computer Methods and Programs in Biomedicine, the scientists presented an "intelligent system" of support for infertility treatments. For this they used information from 63 cases from the infertility programme at Clínica del Pilar in San Sebastian (Guipúzcoa), and analysed the evolution of trios of embryos (Spanish law allows for the transfer of up to three embryos to a woman's uterus).
To prepare the study, the researchers focused on the case history of infertile couples (age, type of infertility, quality of sperm, etc), as well as the morphological characteristics of the zygote (the resulting cell from the fusion of two gametes) and the embryos.
From the images taken with the microscope, the scientists were able to measure and classify the zygotes and embryos, as well as the blastomeres (undifferentiated animal cells produced by the division of the zygote), their degree of fragmentation and the thickness of the ‘zona pellucida', a membrane that surrounds them.
All this information was processed with Bayesian classifiers, so-called due to the application of Bayes rules, which make it possible to calculate the probability of implanting an embryo in a woman's uterus if transferred there. "What's more, these types of mathematical classifiers provide experts with evidence on what embryo characteristics enable the identification of the most ideal embryos, through the selection of variables", explained Morales.
The results of this study indicate that the size and degree of fragmentation of the blastomeres, thickness of the zona pellucida and the fact that they might have various nuclei are some of the aspects embryologists should concentrate on.
The Basque research group also carried out a second study, published in the journal Computers in Biology and Medicine to check the effectiveness of different Bayesian classifiers as a tool for choosing the best embryo.
The researchers analysed 249 photographs of embryos from the database at the Genesis Centre in Rome (Italy) and discovered that the "wrapper-TAN" classifier had a success rate of over 90%.
The team's next lines of work will concentrate on perfecting these techniques for selecting the best embryo in infertility treatments and in predicting multiple pregnancies, due to the risk they pose to women. The scientists will try to collaborate with other hospitals in this task.
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